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Their conclusion: sleep improvement under DSIP treatment is of little clinical significance. [11] Bes and colleagues in Amsterdam ran a double-blind matched-pairs parallel-groups design in 16 chronic insomniacs and found the statistically significant effects were weak and in part could be due to an incidental change in the placebo group, with subjective sleep quality unchanged

However, some users report cardiovascular effects including rapid heartbeat, chest pain, or dizziness, particularly with excessive application or use on compromised skin barriers

The greatest avoidable dangers come from poor sourcing and unsupervised use

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This rigorous methodology minimizes bias and allows for accurate attribution of adverse effects to the intervention rather than background health conditions or placebo effects

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